Literature on EDEM2
EDEM2 [ENSP00000363616]
ER degradation-enhancing alpha-mannosidase-like protein 2; Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner . May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 . Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).
Synonyms: EDEM2, EDEM2p, hEDEM2, MMP24-AS1-EDEM2, Q9BV94 ...