DISEASES

Disease-gene associations mined from literature

Literature on GADD45GIP1

GADD45GIP1 [ENSP00000323065]

Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protein mL64 family.

Synonyms:  GADD45GIP1,  Q8TAE8,  Q8TAE8p,  hQ8TAE8,  39S ribosomal protein L59, mitochondrial ...

Linkouts:  STRING  Pharos  UniProt  OMIM