DISEASES

Disease-gene associations mined from literature

Literature on DBF4

DBF4 [ENSP00000265728]

Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7- DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.

Synonyms:  DBF4,  DBF4p,  hDBF4,  B4DXK0,  F8WF77 ...

Linkouts:  STRING  Pharos  UniProt  OMIM