DISEASES

Disease-gene associations mined from literature

Literature on POLR2I

POLR2I [ENSP00000221859]

DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).

Synonyms:  POLR2I,  POLR2Ip,  hPOLR2I,  K7EK49,  K7EKS1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM