DISEASES

Disease-gene associations mined from literature

Literature on LPCAT1

LPCAT1 [ENSP00000283415]

Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities . Activity is calcium- independent (By similarity). Mediates the conversion of 1-acyl-sn- glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) . Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively . May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology . Involved in the regulation of lipid droplet number and size .

Synonyms:  LPCAT1,  LPCAT1p,  hLPCAT1,  Q8NF37,  Q8NF37p ...

Linkouts:  STRING  Pharos  UniProt  OMIM