DISEASES

Disease-gene associations mined from literature

Literature on GPI

GPI [ENSP00000405573]

Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis . Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility . Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons . It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion .

Synonyms:  GPI,  A0A0A0MTS2,  A0A0G2JLI6,  A0A2R8Y6C7,  A0A2R8YF08 ...

Linkouts:  STRING  Pharos  UniProt  OMIM