DISEASES

Disease-gene associations mined from literature

Literature on FDPS

FDPS [ENSP00000349078]

Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate; Belongs to the FPP/GGPP synthase family.

Synonyms:  FDPS,  A0A087WTP2,  A0A087WVN4,  A0A087X090,  A0A087X1D8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM