DISEASES

Disease-gene associations mined from literature

Literature on TG

TG [ENSP00000220616]

Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) . The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (By similarity). Following TG re- internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity).

Synonyms:  TG,  E5RG33,  E7EVM0,  H0YB42,  H0YBC5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM