DISEASES

Disease-gene associations mined from literature

Literature on RNF5

RNF5 [ENSP00000364235]

E3 ubiquitin-protein ligase RNF5; Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966,

Synonyms:  RNF5,  RNF5p,  hRNF5,  A0A024RCQ4,  Q99942 ...

Linkouts:  STRING  Pharos  UniProt  OMIM