DISEASES

Disease-gene associations mined from literature

Literature on TRIM25

TRIM25 [ENSP00000323889]

E3 ubiquitin/ISG15 ligase TRIM25; Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase . Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849). Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection . Mediates 'Lys-63'- linked polyubiquitination of IFIH1 . Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs . Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 . ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784,

Synonyms:  TRIM25,  TRIM25p,  hTRIM25,  A0A3B3IUA7,  I3L2W4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM