DISEASES

Disease-gene associations mined from literature

Literature on C1D

C1D [ENSP00000348107]

Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). ECO:0000269|PubMed:10362552, ECO:0000269|PubMed:11801738,

Synonyms:  C1D,  C1Dp,  hC1D,  J3KPZ4,  Q13901 ...

Linkouts:  STRING  Pharos  UniProt  OMIM