DISEASES

Disease-gene associations mined from literature

Literature on MEOX2

MEOX2 [ENSP00000262041]

Homeobox protein MOX-2; Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner . May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Synonyms:  MEOX2,  MEOX2p,  hMEOX2,  P50222,  P50222p ...

Linkouts:  STRING  Pharos  UniProt  OMIM