DISEASES

Disease-gene associations mined from literature

Literature on MSL1

MSL1 [ENSP00000462945]

Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure . Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) . This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 . In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation .

Synonyms:  MSL1,  MSL1p,  hMSL1,  J3KRQ4,  J3KSZ8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM