DISEASES

Disease-gene associations mined from literature

Literature on KIF5A

KIF5A [ENSP00000408979]

Kinesin heavy chain isoform 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.

Synonyms:  KIF5A,  KIF5Ap,  hKIF5A,  J3KNA1,  Q12840 ...

Linkouts:  STRING  Pharos  UniProt  OMIM