DISEASES

Disease-gene associations mined from literature

Literature on MAP1LC3A

MAP1LC3A [ENSP00000363970]

Microtubule-associated proteins 1A/1B light chain 3A; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation . Through its interaction with the reticulophagy receptor TEX264, paticipates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover .

Synonyms:  MAP1LC3A,  Q9H492,  Q9H492p,  hQ9H492,  3ECI ...

Linkouts:  STRING  Pharos  UniProt  OMIM