DISEASES

Disease-gene associations mined from literature

Literature on CDC16

CDC16 [ENSP00000348554]

Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. ; Belongs to the APC6/CDC16 family.

Synonyms:  CDC16,  CDC16p,  hCDC16,  A0A024RDZ2,  A0A3B3ISD2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM