DISEASES

Disease-gene associations mined from literature

Literature on SHPRH

SHPRH [ENSP00000275233]

E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'; Belongs to the SNF2/RAD54 helicase family.

Synonyms:  SHPRH,  A0A0D9SFM0,  H0YBI0,  H7C2W2,  K4DI94 ...

Linkouts:  STRING  Pharos  UniProt  OMIM