DISEASES

Disease-gene associations mined from literature

Literature on RASGRF2

RASGRF2 [ENSP00000265080]

Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.

Synonyms:  RASGRF2,  RASGRF2p,  hRASGRF2,  A0A1W2PP99,  A0A2X0SFL3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM