DISEASES

Disease-gene associations mined from literature

Literature on ZNF521

ZNF521 [ENSP00000354794]

Zinc finger protein 521; Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes; Belongs to the krueppel C2H2-type zinc-finger protein family.

Synonyms:  ZNF521,  ZNF521p,  hZNF521,  H7BYU6,  J3KSZ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM