DISEASES

Disease-gene associations mined from literature

Literature on SLC5A12

SLC5A12 [ENSP00000379326]

Sodium-coupled monocarboxylate transporter 2; Acts as an electroneutral and low-affinity sodium (Na(+))- dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity); Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Synonyms:  SLC5A12,  SLC5A12p,  hSLC5A12,  E9PLZ7,  G3V1E3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM