DISEASES

Disease-gene associations mined from literature

Literature on MARK3

MARK3 [ENSP00000411397]

MAP/microtubule affinity-regulating kinase 3; Serine/threonine-protein kinase . Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU . Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus . Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 .

Synonyms:  MARK3,  MARK3p,  hMARK3,  A0A0A0MSZ1,  A2SY06 ...

Linkouts:  STRING  Pharos  UniProt  OMIM