DISEASES

Disease-gene associations mined from literature

Literature on BMT2

BMT2 [ENSP00000297145]

S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes . Acts as a sensor of S-adenosyl-L- methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling . Upon methionine starvation, S-adenosyl-L- methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling . Probably also acts as a S-adenosyl-L-methionine- dependent methyltransferase (Potential); Belongs to the BMT2 family.

Synonyms:  BMT2,  BMT2p,  hBMT2,  H0Y6Y0,  Q1RMZ1 ...

Linkouts:  STRING  Pharos  UniProt