DISEASES

Disease-gene associations mined from literature

Literature on WARS1

WARS1 [ENSP00000347495]

Tryptophan--tRNA ligase, cytoplasmic; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress- responsive gene expression. ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:1373391,

Synonyms:  WARS1,  WARS1p,  hWARS1,  A0A024R6K8,  G3V227 ...

Linkouts:  STRING  Pharos  UniProt  OMIM