DISEASES

Disease-gene associations mined from literature

Literature on CLCA2

CLCA2 [ENSP00000359596]

Calcium-activated chloride channel regulator 2, 109 kDa form; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:11445004,; Belongs to the CLCR family.

Synonyms:  CLCA2,  CLCA2p,  hCLCA2,  Q9UQC9,  Q9UQC9p ...

Linkouts:  STRING  Pharos  UniProt  OMIM