DISEASES

Disease-gene associations mined from literature

Literature on BAIAP2

BAIAP2 [ENSP00000316338]

Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031,

Synonyms:  BAIAP2,  BAIAP2p,  hBAIAP2,  B4DWA1,  I3L0M4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM