Literature on TRIM39
TRIM39 [ENSP00000365844]
E3 ubiquitin-protein ligase TRIM39; [Isoform 1]: E3 ubiquitin-protein ligase . May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly- ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 . Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex- mediated CDKN1A/p21 ubiquitination and degradation .
Synonyms: TRIM39, TRIM39p, hTRIM39, A0A024RCP5, A0A024RCR1 ...