DISEASES

Disease-gene associations mined from literature

Literature on RCHY1

RCHY1 [ENSP00000321239]

RING finger and CHY zinc finger domain-containing protein 1; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21791603,

Synonyms:  RCHY1,  RCHY1p,  hRCHY1,  D6RAF6,  H0YAI4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM