DISEASES

Disease-gene associations mined from literature

Literature on TBR1

TBR1 [ENSP00000374205]

T-box brain protein 1; Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection . As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).

Synonyms:  TBR1,  TBR1p,  hTBR1,  H7C0B1,  Q16650 ...

Linkouts:  STRING  Pharos  UniProt  OMIM