Literature on PPM1D
PPM1D [ENSP00000306682]
Protein phosphatase 1D; Involved in the negative regulation of p53 expression . Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins . Mediates MAPK14 dephosphorylation and inactivation . Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). ECO:0000269|PubMed:16311512, ECO:0000269|PubMed:21283629,
Synonyms: PPM1D, PPM1Dp, hPPM1D, A0A0S2Z4M2, K7EJH1 ...