DISEASES

Disease-gene associations mined from literature

Literature on CCN4

CCN4 [ENSP00000250160]

CCN family member 4; Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan; Belongs to the CCN family.

Synonyms:  CCN4,  CCN4p,  hCCN4,  E5RG88,  O95388 ...

Linkouts:  STRING  Pharos  UniProt  OMIM