DISEASES

Disease-gene associations mined from literature

Literature on SIGLEC8

SIGLEC8 [ENSP00000321077]

Sialic acid-binding Ig-like lectin 8; Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface . Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6- sulfated sialyl-Lewis X glycan epitopes .

Synonyms:  SIGLEC8,  SIGLEC8p,  hSIGLEC8,  C9JT30,  Q9NYZ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM