DISEASES

Disease-gene associations mined from literature

Literature on HPN

HPN [ENSP00000262626]

Serine protease hepsin non-catalytic chain; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL . Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 . Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization . ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26673890,; Belongs to the peptidase S1 family.

Synonyms:  HPN,  A0A140VJK9,  M0QZ63,  M0R244,  P05981 ...

Linkouts:  STRING  Pharos  UniProt  OMIM