DISEASES

Disease-gene associations mined from literature

Literature on DENR

DENR [ENSP00000280557]

Density-regulated protein; May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

Synonyms:  DENR,  A0A024RBR3,  F8VVL1,  O43583,  F8VVL1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM