DISEASES

Disease-gene associations mined from literature

Literature on CCNT2

CCNT2 [ENSP00000264157]

Cyclin-T2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II) . The activity of this complex is regulated by binding with 7SK snRNA . Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 . Involved in early embryo development (By similarity). ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843,

Synonyms:  CCNT2,  CCNT2p,  hCCNT2,  C9JUL2,  F2Z2C9 ...

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