Literature on CLEC4A
CLEC4A [ENSP00000229332]
C-type lectin domain family 4 member A; C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner . Involved in regulating immune reactivity . Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 . In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production . May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation . ECO:0000269|PubMed:18258799, ECO:0000269|PubMed:20530286,
Synonyms: CLEC4A, CLEC4Ap, hCLEC4A, A0A286YF15, Q9UMR7 ...