DISEASES

Disease-gene associations mined from literature

Literature on GID8

GID8 [ENSP00000266069]

Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 . Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation ; Belongs to the GID8 family.

Synonyms:  GID8,  GID8p,  hGID8,  Q9NWU2,  Q9NWU2p ...

Linkouts:  STRING  Pharos  UniProt