DISEASES

Disease-gene associations mined from literature

Literature on CCDC65

CCDC65 [ENSP00000312706]

Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules . ; Belongs to the DRC2 family.

Synonyms:  CCDC65,  CCDC65p,  hCCDC65,  F8VR42,  F8W0R6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM