DISEASES

Disease-gene associations mined from literature

Literature on AGBL5

AGBL5 [ENSP00000353249]

Cytosolic carboxypeptidase-like protein 5; Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.

Synonyms:  AGBL5,  AGBL5p,  hAGBL5,  C9JCE1,  C9JHM6 ...

Linkouts:  STRING  Pharos  UniProt