DISEASES

Disease-gene associations mined from literature

Literature on DLX1

DLX1 [ENSP00000354478]

Homeobox protein DLX-1; Plays a role as a transcriptional activator or repressor . Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation . Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). ; Belongs to the distal-less homeobox family.

Synonyms:  DLX1,  DLX1p,  hDLX1,  F8VXJ2,  J3KP55 ...

Linkouts:  STRING  Pharos  UniProt  OMIM