DISEASES

Disease-gene associations mined from literature

Literature on MIB2

MIB2 [ENSP00000426103]

E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

Synonyms:  MIB2,  MIB2p,  hMIB2,  D6R9Q6,  D6RAZ0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM