DISEASES

Disease-gene associations mined from literature

Literature on RANBP9

RANBP9 [ENSP00000011619]

Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement . Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 . May be involved in signaling of ITGB2/LFA-1 and other integrins . Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway . Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation . Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity . Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118,

Synonyms:  RANBP9,  RANBP9p,  hRANBP9,  A0A024QZW3,  Q96S59 ...

Linkouts:  STRING  Pharos  UniProt  OMIM