DISEASES

Disease-gene associations mined from literature

Literature on PDE12

PDE12 [ENSP00000309142]

2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP . Also cleaves 3',5'-phosphodiester bond of oligoadenylates . Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells . ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541,

Synonyms:  PDE12,  PDE12p,  hPDE12,  F6T1Q0,  Q6L8Q7 ...

Linkouts:  STRING  Pharos  UniProt