DISEASES

Disease-gene associations mined from literature

Literature on ACOD1

ACOD1 [ENSP00000366682]

Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

Synonyms:  ACOD1,  ACOD1p,  hACOD1,  A6NK06,  H7C1Q4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM