DISEASES

Disease-gene associations mined from literature

Literature on CDT1

CDT1 [ENSP00000301019]

DNA replication factor Cdt1; Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre- replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments . Potential oncogene (By similarity). ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055,; Belongs to the Cdt1 family.

Synonyms:  CDT1,  CDT1p,  hCDT1,  H3BSY1,  Q9H211 ...

Linkouts:  STRING  Pharos  UniProt  OMIM