DISEASES

Disease-gene associations mined from literature

Literature on KLF17

KLF17 [ENSP00000361373]

Krueppel-like factor 17; Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Synonyms:  KLF17,  KLF17p,  hKLF17,  A0A0U1RR65,  Q5JT82 ...

Linkouts:  STRING  Pharos  UniProt  OMIM