DISEASES

Disease-gene associations mined from literature

Literature on CACNA1E

CACNA1E [ENSP00000356545]

Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells . They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Synonyms:  CACNA1E,  CACNA1Ep,  hCACNA1E,  A0A2R8Y7W1,  E9PIE8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM