DISEASES

Disease-gene associations mined from literature

Literature on H2BC21

H2BC21 [ENSP00000358151]

Histone H2B type 2-E; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  H2BC21,  H2BC21p,  hH2BC21,  HIST2H2BE,  Q16778 ...

Linkouts:  STRING  Pharos  UniProt  OMIM