DISEASES

Disease-gene associations mined from literature

Literature on H2BC5

H2BC5 [ENSP00000289316]

Histone H2B type 1-D; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  H2BC5,  H2BC5p,  hH2BC5,  A0A024QZZ7,  HIST1H2BD ...

Linkouts:  STRING  Pharos  UniProt  OMIM