DISEASES

Disease-gene associations mined from literature

Literature on PDE3B

PDE3B [ENSP00000282096]

cGMP-inhibited 3',5'-cyclic phosphodiesterase B; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Synonyms:  PDE3B,  PDE3Bp,  hPDE3B,  Q13370,  Q13370p ...

Linkouts:  STRING  Pharos  UniProt  OMIM