DISEASES

Disease-gene associations mined from literature

Literature on SPC25

SPC25 [ENSP00000282074]

Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules . ; Belongs to the SPC25 family.

Synonyms:  SPC25,  SPC25p,  hSPC25,  C9JW94,  Q9HBM1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM